Figure 1. Prenatal vitamin D supplementation and asthma or recurrent wheeze in offspring at age 3 years, stratified by initial maternal 25OHD.
The effect on prevention of childhood asthma and recurrent wheeze was greatest in children born to mothers who had initial 25OHD levels of at least 40 ng/ml and who were randomized to 4,400 IU/day of cholecalciferol (odds ratio=0.13, 95%CI=0.02,0.99). There was a significant trend over the effects of categories of 25OHD in the 4,400 IU/day arm (p=0.03). Figure is redrawn from data presented in Table E5 in the online repository of Wolsk, et al.(**15)