Table 2 –

Multivariable Cox Regression and Competing Risks Regression Analyses: Variables Associated with Post-transplant HCC Recurrence

	Multivariable Cox Regression		Competing Risks Regression
	Hazard Ratio (95% CI)	p-value	Subhazard Ratio (95% CI)	p-value
Variables of Interest
Etiology (ref = HCV)
HBV	1.10 (0.83 – 1.45)	0.514	1.14 (0.86 – 1.51)	0.359
EtOH	0.65 (0.51 – 0.83)	0.001*	0.66 (0.52 – 0.85)	0.001*
NAFLD	0.87 (0.69 – 1.09)	0.223	0.88 (0.70 – 1.10)	0.267
Autoimmune	0.87 (0.58 – 1.31)	0.510	0.90 (0.60 – 1.36)	0.612
Other	1.10 (0.92 – 1.32)	0.294	1.13 (0.94 – 1.35)	0.202
Max AFP Range (ng/mL; ref <100)
100 – 499	2.08 (1.77 – 2.45)	<0.001*	2.02 (1.72 – 2.38)	<0.001*
500 – 1000	2.34 (1.73 – 3.17)	<0.001*	2.26 (1.65 – 3.08)	<0.001*
>1000	4.06 (3.20 – 5.16)	<0.001*	3.73 (2.92 – 4.77)	<0.001*
Etiology-AFP Range Interaction		0.006*		0.015*
Covariates
Age (per 5 years)	1.05 (1.01 – 1.09)	0.008*	1.04 (1.00 – 1.08)	0.041*
Male Sex	1.36 (1.18 – 1.55)	<0.001*	1.36 (1.19 – 1.55)	<0.001*
Race (ref = white)
Black	0.77 (0.64 – 0.93)	0.007*	0.73 (0.60 – 0.88)	0.001*
Hispanic	0.82 (0.70 – 0.96)	0.015*	0.82 (0.70 – 0.97)	0.017*
Asian	0.84 (0.68 – 1.04)	0.107	0.87 (0.70 – 1.08)	0.211
Other	0.69 (0.42 – 1.13)	0.136	0.69 (0.41 – 1.15)	0.152
Waiting Time (per 3 months)	0.99 (0.98 – 1.00)	0.013*	0.99 (0.98 – 1.00)	0.022*
Largest Tumor at Transplant (cm)	1.11 (1.08 – 1.13)	<0.001*	1.11 (1.07 – 1.15)	<0.001*
Within Milan Criteria at Transplant	0.76 (0.60 – 0.96)	0.020*	0.77 (0.61 – 0.98)	0.031*
Locoregional Therapy Prior to Transplant	1.27 (1.13 – 1.43)	<0.001*	1.29 (1.14 – 1.44)	<0.001*
Downstaged Prior to Transplant	1.53 (1.09 – 2.14)	0.014*	1.53 (1.09 – 2.16)	0.014*

^*Statistically significant at the alpha = 0.05 level

^**MELD pre-transplant and number of viable tumors at transplant were not statistically significant at the alpha = 0.05 level and were removed from these models