Table 3 –

Multivariable Competing Risks Regression Results: Subhazard Ratios Derived from Interaction between Etiology of Liver Disease and Max AFP range (ng/mL)

Variable	Subhazard Ratio (95% CI)	p-value
HCV
AFP <100	1 (reference)
AFP 100 – 499	2.02 (1.72 – 2.38)	<0.001*
AFP 500 – 1000	2.26 (1.65 – 3.08)	<0.001*
AFP >1000	3.73 (2.92 – 4.77)	<0.001*
HBV
AFP <100	1 (reference)
AFP 100 – 499	1.24 (0.67 – 2.29)	0.489
AFP 500 – 1000	2.62 (1.27 – 5.40)	0.009*
AFP >1000	1.97 (0.97 – 4.03)	0.062
EtOH
AFP <100	1 (reference)
AFP 100 – 499	4.69 (2.92 – 7.52)	<0.001*
AFP 500 – 1000	6.57 (2.75 – 15.68)	<0.001*
AFP >1000	7.20 (3.75 – 13.81)	<0.001*
NAFLD
AFP <100	1 (reference)
AFP 100 – 499	1.55 (0.83 – 2.89)	0.168
AFP 500 – 1000	2.22 (0.76 – 6.52)	0.145
AFP >1000	3.26 (1.39 – 7.65)	0.007*
Autoimmune
AFP <100	1 (reference)
AFP 100 – 499	2.55 (1.18 – 5.50)	0.017*
AFP 500 – 1000	1.58 (0.23 – 10.65)	0.640
AFP >1000	2.10 (0.52 – 8.52)	0.300
Other
AFP <100	1 (reference)
AFP 100 – 499	1.90 (1.35 – 2.69)	<0.001*
AFP 500 – 1000	2.42 (1.33 – 4.40)	0.004*
AFP >1000	1.81 (1.01 – 3.23)	0.045

^*Statistically significant at the alpha = 0.017 level (Bonferroni corrected)