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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Curr Med Chem. 2019;26(33):6132–6148. doi: 10.2174/0929867325666180831150259

Figure 5. EGFR-mediated exosome delivery of miRNA.

Figure 5.

A. Electron microscope images depicting the presence of GE11 and EGF on the exosome surface. B. Confocal microscope images depicting PKH67 dye-loaded exosomes (green) internalized within HCC70 human breast cancer cells. C. In vivo imaging comparing normal exosome and GE11-modified exosomes accumulation within a human breast cancer tumor-bearing mouse model. D. Antitumor effect 4 week following post-administration of let7a miRNA-containing exosomes. Reprint with permission from ref [91].