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The protein domains within RUNX1 are diagrammed including the Runt Homology Domain (RHD, DNA and CBF-β binding), Nuclear Localization Signal (NLS), Nuclear Matrix Targeting Signal (NMTS), Activation Domain (AD), Inhibitory Domain (ID), and VWRPY domains. The exons of RUNX1 that correspond to these domains are also shown. Diagrams of the three RUNX factors are displayed. RUNX2 also contains a polyglutamate-alanine rich QA domain.
