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. Author manuscript; available in PMC: 2019 Mar 28.
Published in final edited form as: J Med Chem. 2019 Feb 13;62(4):1761–1780. doi: 10.1021/acs.jmedchem.8b01679

Table 7.

Pharmacokinetic Profile of Compound 58 in Rodentsa

i.v. (rat, 1 mg·kg−1; mice, 3 mg·kg−1) p.o. (rat, 5 mg kg−1; mice, 10 mg·kg−1)
CL (mL·min−1·kg−1) T ½ (h) AUC0-t (h·ng mL−1) Vss (L·kg−1) T ½ (h) Cmax (ng mL−1) AUC0-t (h·ng mL−1) F (%)
Mice 66.5 1.91 725 7.72 2.57 80.9 265 12
Rats (fed) 105 1.81 153 13.8 6.19 39.1 232 30.2
a

58 was dosed as the monotartrate salt.