Table 3.
Characteristics of Breast Cancers Detected
| ID | Mutant gene | Prior breast cancer | Prior BSO | Age breast ca dx | Cancer type | Grade | ER | PR | HER2 | MRI lesion (cm) | Invasive tumor (cm) | Positive nodes | Stage | Detection modality | Detection round |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BRCA1 | none | yes | 42 | DCIS only | 3 | nd | nd | nd | 0.9 (MF) | 0/4 | Stage 0 | both | 1st screening round | |
| 2 | BRCA1 | none | yes | 55 | IDC | 3 | pos | neg | neg | 0.4 | 0.3 | 0/4 | Stage 1 | both | 1st screening round |
| 3 | BRCA1 | CL | no | 27 | IDC + DCIS | 3 | pos | neg | nd | 1.2 | 0.1 | 0/2 | Stage 1 | MRI | 1st screening round |
| 4 | none | IL | no | 37 | IDC + DCIS | 3 | pos | pos | neg | 0.9 | 1.0 | 0/1 | Stage 1 | MRI | 1st screening round |
| 5 | BRCA1 | CL | yes | 46 | DCIS only | 3 | nd | nd | nd | 0.3 | 0/1 | Stage 0 | MRI | MRI interval round | |
| 6 | BRCA1 | CL | yes | 43 | IDC + DCIS | 2 | neg | neg | neg | 0.7 | 0.7 | 0/5 | Stage 1 | MRI | MRI interval round |
| 7 | none | CL | yes | 59 | IDC + DCIS | 2 | pos | pos | neg | 0.6 | 0.6 | 0/4 | Stage 1 | MRI | MRI interval round |
| 8 | BRCA1 | CL | yes | 43 | IDC + DCIS | 2 | pos | pos | neg | 1.0 | NAC (0.9) | 0/3 | Stage 1 | MRI | MRI + MG round |
| 9 | BRCA1 | none | yes | 51 | DCIS only | 3 | nd | nd | nd | 0/4 | Stage 0 | MG | MRI + MG round | ||
| 10 | CDH1 | none | no | 75 | ILC + LCIS | 1 | pos | neg | neg | 1.6 | 0.8 | 0/1 | Stage 1 | both | MRI + MG round |
| 11 | BRCA2 | CL | yes | 66 | IDC + DCIS | 3 | neg | neg | neg | 1.1 | NAC (0) | 0/3 | Stage 1 | both | MRI + MG round |
| 12 | BRCA1 | IL | yes | 61 | IDC + DCIS | 3 | pos | pos | neg | 0.9 | 0.8 | 0/2 | Stage 1 | MRI | MRI interval round |
| 13 | BRCA1 | none | no | 43 | IDC + DCIS | 3 | pos | neg | neg | 1.2 | 0.9 | 0/2 | Stage 1 | MRI | MRI interval round |
| 14 | BRCA1 | CL | yes | 50 | IDC + DCIS | 3 | neg | neg | neg | 1.3 | 0.4 | 0/2 | Stage 1 | both | MRI + MG round |
| 15 | BRCA2 | none | yes | 48 | IDC + DCIS | 3 | pos | pos | neg | 0.9 | 0.6 | 0/4 | Stage 1 | MRI | MRI interval round |
| 16 | BRCA1 | none | yes | 55 | IDC + DCIS | 3 | neg | neg | neg | 0.8 | 0.5 | 0/2 | Stage 1 | both | MRI + MG round |
| 17 | BRCA2 | none | Yes | 36 | DCIS only | 2 | pos | pos | nd | 0/0 | Stage 0 | none | PMS | ||
Abbreviations: BSO, bilateral salpingo-oophorectomy; CL, contralateral; DCIS, ductal carcinoma in situ; ER, estrogen receptor; HER2, HER2 receptor; IDC, invasive ductal cancer; ILC, invasive lobular cancer; IP, ipsilateral; LCIS, lobular carcinoma in situ; MF, multifocal (9 mm biggest); MG, mammography; MRI, dynamic contrast-enhanced magnet resonance imaging; NAC, neoadjuvant chemotherapy; nd, not done; neg, negative; PMS, prophylactic mastectomy specimen; pos, positive; PR, progesterone receptor. Symbols: +, plus.