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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Biomaterials. 2018 Aug 31;198:259–269. doi: 10.1016/j.biomaterials.2018.08.058

Figure 6. Effects of electrical stimulation on calcium handling in myobundles.

Figure 6.

(A) Representative traces of gCaMP6-reported Ca2+ transient signal from myobundles stimulated at 1Hz (twitch) and 20Hz (tetanus). (B) Quantified amplitudes of Ca2+ transients (n = 12 myobundles from N = 3 donors per group). (C) Representative twitch traces in non-stimulated (CTL) and 1 and 10Hz stimulated myobundles. (D) Time-to-peak tension (TPT), (E) Half-relaxation time (1/2RT) and (F) 90% decay time (n = 66 – 98 myobundles from N = 9 donors per group). (G)Quantified mRNA expression of calcium-handling related genes (n = 9 – 12 myobundles from N = 3 donors per group). *, P<0.05 vs. CTL; #, P<0.05 vs. 1Hz.