Table 1.
Comparison of baseline characteristics between participants with vs. without use of iron supplements (N=1165*)
| Iron use at baseline | |||
|---|---|---|---|
| Baseline characteristics | No (N=984) | Yes (N=181) | P-value |
| Age (years): Mean (SD) | 79.0 (7.6) | 80.2 (6.9) | 0.04 |
| Female (%) | 609 (61.9%) | 112 (61.9%) | 1.00 |
| Former or current cigarette smoker (%) | 559 (56.8%) | 106 (58.6%) | 0.66 |
| Taking AREDS supplement (%) | 586 (59.6%) | 150 (82.9%) | <0.0001 |
| Presence of diabetes (%) | 166 (16.9%) | 37 (20.4%) | 0.24 |
| Presence of hypertension (%) | 674 (68.5%) | 128 (70.7%) | 0.55 |
| Systolic BP (mmHg): mean (SD) | 135 (17.9) | 133 (16.7) | 0.09 |
| Diastolic BP (mmHg): mean (SD) | 76 (10.1) | 75 (9.7) | 0.59 |
| History of cardiovascular diseases | 217 (22.1%) | 59 (32.6%) | 0.002 |
| Osteoarthritis | 452 (45.9%) | 95 (52.5%) | 0.11 |
| Rheumatoid arthritis | 56 (5.7%) | 13 (7.2%) | 0.43 |
| Anemia | <0.0001 | ||
| None | 834 (90.9%) | 127 (70.2%) | |
| Past | 42 (4.3%) | 25 (13.8%) | |
| Ongoing | 48 (4.9%) | 29 (16.0%) | |
| Baseline use of antiplatelet or anticoagulant drug (%) | 501 (50.9%) | 107 (59.1%) | 0.04 |
| CNV in the fellow eye | 296 (30.1%) | 9 (27.1%) | 0.42 |
| Visual acuity in study eye: Mean (SD) in letters | 60.4 (13.5) | 60.9 (13.6) | 0.61 |
| Total area of CNV lesion (disc area): mean (SD) | 2.5 (2.5) | 2.3 (2.6) | 0.29 |
| Total retinal thickness (microns): mean (SD) | 462 (189) | 463 (178) | 0.94 |
SD=Standard deviation, BP=blood pressure, CNV=Choroid neovascularization.
*
Of 1185 CATT participants, 20 patients did not have good image quality images for determining retinal/subretinal hemorrhage, leaving 1165 participants for analysis.
†
Adjusted by age, gender, smoking status, dietary supplement use, hypertension, diabetes, CVD history, use of antiplatelet or anticoagulant, and CNV in fellow eye.