Table 3.
Comparison of neurological diseases/disorders of DEGs uniquely found in males or females.
| Diseases or Functions Annotation | P-values (number of genes) | Diseases or Functions Annotation | P-values (number of genes) |
|---|---|---|---|
| Males | Females | ||
| Huntington’s Disease | 6.67E-03 (40) | Disorder of basal ganglia | 2.72E-04 (122) |
| Pervasive developmental disorder | 2.20E-02 (17) | Dementia | 1.90E-04 (118) |
| Autism | 1.18E-02 (10) | Tauopathy | 3.82E-05 (117) |
| Alcohol withdrawal syndrome | 3.15E-02 (4) | Alzheimer disease | 1.66E-04 (110) |
| Susceptibility to Alzheimer disease | 7.03E-03 (3) | Pervasive developmental disorder | 1.44E-04 (41) |
The lists of genes that were dysregulated only in males or females were used to predict the neurological diseases/disorders associated with ASD using IPA. Significance was determined by the Fisher’ exact test, with a P-value = 0.05 as the cutoff.