Table 6.
Significant canonical pathways associated with our DEGs that were also identified as BPA-responsive genes in other independent studies.
| Canonical Pathways | P-values | Genes |
|---|---|---|
| Aldosterone Signaling in Epithelial Cells | 2.14E-04 | RAF1, HSPH1, SLC12A2, TRAP1, DNAJC13, HSPD1, HSPA2, HSPA8, PIK3R3, HSP90B1, PLCB4, PIK3C3, PRKCD, PIK3CD, DNAJB6, PRKD3, HSPB6, HSPA4L, HSPB1 |
| PTEN Signalingop | 1.62E-03 | RAF1, YWHAH, BAD, ITGA5, NFKB2, CCND1, SYNJ2, PIK3R3, GHR, PIK3CD, INSR, FGFRL1, FASLG, PDGFRB |
| PPARα/RXRα Activation | 5.75E-03 | RAF1, IL1RL1, MED1, NFKB2, TGS1, PRKAG1, HSP90B1, PLCB4, GHR, GPD2, LPL, SMAD4, NCOR1, INSR, NFKBIB, MED24 |
| Dendritic Cell Maturation | 1.02E-02 | LEP, FCGR2A, HLA-A, TYROBP, HLA-DQA1, NFKB2, MAPK11, PIK3R3, PLCB4, PIK3C3, CD86, ATF4, PIK3CD, TLR3, IL23A, NFKBIB |
| Circadian Rhythm Signaling | 1.78E-02 | PER1, GRIN2A, ATF4, VIP, PER2 |
The list of DEGs in the hippocampus was overlapped with the list of BPA-responsive genes identified by other studies. Canonical pathways associated with the overlapping genes were analyzed by IPA software. P-values were calculated using Fisher’s exact test (P < 0.05).