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. 2019 Feb 28;9:3180. doi: 10.1038/s41598-019-40061-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Shuttle-box behavior during the adolescent period. Means and SEM are represented. (A) Number of avoidance and escape responses in CST rats (n = 56). (B) Number of inter-crossings during the 5 min habituation previous to each shuttle-box session in CST and UST (n = 58) rats. ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001 versus UST rats. (C) Time (%) spent freezing during the habituation period of sessions 2 and 8 in a sub-set CST and UST rats (n = 46–47/group). The effect of time is not represented.