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. 2019 Feb 28;9:3161. doi: 10.1038/s41598-019-39341-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological and immunohistochemical (IHC) analysis of the endogenous immune response to the drNPC-SPRPix implanted into the brain cortex of a rhesus macaque. (A) Nissl stain; magnification ×100 (B,С). H&E stain of the interface between the SPRPix and the surrounding host tissue; magnifications ×100 (B) and ×200 (С). (D,E). Representative images of CD3 staining showing low level of T cell infiltration in the brain tissue adjacent to the drNPC-SPRPix implant. (F–H) Representative images of CD68 staining showing examples of microglial/macrophages in the brain adjacent to the drNPC-SPRPix implant (G) and among the human cell graft (H). (E,H) depict the areas with the highest immune cell infiltration noted. Bar size 100 µm. Notations: rSS-PCL-spidroin-polycaprolactone scaffold; Ctx – brain cortex.