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. 2019 Feb 28;9:3096. doi: 10.1038/s41598-019-39650-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the predicted secretion pathways of various secretomes. Four different secretomes were analyzed for their predicted secretion pathways by using three bioinformatics programs, SignalP, SecretomeP and TMHMM. Proteins in each secretome were classified into four categories based on the predicted secretion pathway (classical secretion, nonclassical secretion, integral to membrane, and intracellular). The four secretomes are (i) the proteins annotated as ‘secreted’ in the Uniprot protein database (2746 entries, yellow line), (ii) the secretome identified in the SFM of 12 cell lines (3356 proteins, blue line), (iii) the secretome analyzed after reducing the protein complexity of the SCM (585 proteins, orange line) and (iv) the exosome proteins reported by EVpedia to be cited in more than 100 papers (920 proteins, green line)