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. 2019 Feb 28;9:3096. doi: 10.1038/s41598-019-39650-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Upstream regulator analysis of hWJ-MSC secretome. Data illustrate the paracrine factors predicted as upstream regulators and their downstream targets in hWJ-MSC data sets. Activated upstream regulators (z-score ≥ 2) are highlighted in orange at the center of circular diagrams and the downstream targets are arranged along the circumference. Up-regulated and down-regulated proteins in SCM compared to SFM are highlighted in red and green, respectively. Orange and blue dashed lines with arrows indicate predicted direction of activation. Networks for IL1A and IL1B are merged in one network for simplicity.