Table 2.
Upstream regulators of hWJ-MSC secretome known as stem cell paracrine factors.
| Upstream Regulatora | Molecule Type | Activation z-score | p-value of overlap | Target molecules in the dataset |
|---|---|---|---|---|
| TNF | cytokine | 3.333 | 3.44.E-15 | 42 |
| TGFB1 | growth factor | 3.236 | 1.66.E-25 | 48 |
| IL1B | cytokine | 2.668 | 6.10.E-06 | 16 |
| IL1A | cytokine | 2.272 | 5.52.E-06 | 10 |
| IL6 | cytokine | 2.045 | 1.60.E-03 | 9 |
| COL18A1 | other | 0.213 | 9.75.E-06 | 9 |
| HGF | growth factor | −0.285 | 2.34.E-07 | 13 |
| MMP12 | peptidase | 1.36.E-11 | 13 | |
| MMP9 | peptidase | 2.28.E-03 | 3 | |
| TIMP3 | other | 2.59.E-03 | 2 | |
| TGFB2 | growth factor | 6.02.E-03 | 3 |
aAmong the upstream regulators predicted to be linked to hWJ-MSC secretome, only those known as paracrine factors secreted commonly in stem cells are listed37.