Table 2.
surfactant | concentration (%) | MRSA (ATCC BAA-2856) | 3T3 cell | ||
---|---|---|---|---|---|
inhibition of biofilm formation | growth inhibiton | toxicity | toxicity | ||
BZC | 0.0005 | + | + | − | ± |
0.005 | + | + | − | + | |
0.05 | + | + | − | + | |
0.5 | + | + | + | + | |
SDS | 0.0005 | − | − | − | − |
0.005 | − | − | − | + | |
0.05 | + | + | − | + | |
0.5 | + | + | − | + | |
CHAPS | 0.0005 | − | − | − | − |
0.005 | − | − | − | − | |
0.05 | − | − | − | − | |
0.5 | + | − | − | + | |
PS80 | 0.0005 | − | − | − | − |
0.005 | − | − | − | − | |
0.05 | + | − | − | − | |
0.5 | + | − | − | ± |
The bactericidal action and toxicity of different surfactants used is summarized. All effects were graded into three excluding “toxicity” in bacteria (total negative: −, positive: +) using CFU analysis. Toxicity (%-viability reduction) in 3T3 fibroblasts was as follows: 10% ≥: −, 11–50%: ±, 51% ≤: +.