Fig. 1. Maximum changes and all changes from baseline in target lesions in patients with stage IV sarcomas treated with apatinib.

a Maximum changes in target lesions in patients with stage IV sarcoma treated with apatinib. Among 64 patients, 51 were evaluated for response to apatinib (RECIST 1.1). No patients achieved CR, 13 (25.49%) achieved PR once, and 36 (70.59%) achieved SD once. Only two (3.9%) patients suffered from PD, and 49 (96.1%) responded to apatinib monotherapy. b Changes from baseline in target lesions after apatinib treatment in 51 patients with measurable sarcoma lesions. Green lines: target lesions shrank ≥ 30% from baseline; red lines: target lesions increased ≥ 20% from baseline; yellow lines: target lesions initially decreased ≥ 30% and then increased ≥ 20% from baseline; black lines: target lesions changed from 20%–30%