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. 2019 Feb 28;9:3094. doi: 10.1038/s41598-019-39679-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Schematic of mouse genotype. (B) Image of dissected tissue from CAG-CRE-ER^T2 × TIGER mouse cross following 100 μg/g tamoxifen injection at P2 and sacrificed at P4. H, heart, B, brain, LV, liver, S, stomach, K, Kidney. Scale bar, 1 cm. (C) Depth coded volumetric 2 photon microscopy image of CD9-GFP following 100 μg/g tamoxifen injection starting at P2 until sacrifice at P8 in a spleen following CLARITY. Color indicates depth of imaging. Scale bar, 50 μm. (D) Cultured fibroblast treated with tamoxifen from TIGER × CAG-CRE-ER^T2 mice. Scale bar, 12.5 μm (E–H) Sections of TIGER × CAG-CRE-ER^T2 mouse tissue following 100 μg/g tamoxifen at P2 and sacrificed at P4. (E) Coronal section of TIGER × CAG-CRE-ER^T2 mouse near ventricle showing CD9-GFP positive cells. Scale bar, 25 μm. (F) Section of stomach of a TIGER × CAG-CRE-ER^T2 mouse. Scale bar, 25 μm. (G) Section of a heart of a CD9-GFP × CAG-CRE-ER^T2 mouse. (H) Section of kidney of a TIGER × CAG-CRE-ER^T2 mouse. Scale bar, 25 μm.