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. 2019 Feb 28;9:3179. doi: 10.1038/s41598-019-39445-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification and annotation of the dysregulated genes in HFpEF proxy versus Normal physiology. (A) Bar plot showing number of differentially expressed genes between HFpEF proxy and Normal physiology predicted using NOISeq with false discovery rate (FDR) adjusted p-value < 0.05. The x axis represents significantly dysregulated genes and the y axis showing the fold change in log2 scale of the corresponding genes. Down-regulated genes in blue and up-regulated genes in orange. (B) Volcano plot of the differentially expressed genes. The x axis represents fold change in log2 scale of HFpEF proxy versus Normal physiology while the y axis indicates the differences of mean expression between HFpEF proxy and Normal physiology. Each point represents a gene, and significantly expressed genes are highlighted in green. Genes that are significantly expressed (FDR-adjusted p-value < 0.05) and with a difference of mean expression above 3.5 are labelled with gene symbols. (C) Similar to plot “A”, but FDR-adjusted p-value < 0.1. (D) Similar to plot “B” but FDR-adjusted p-value < 0.1. Genes that are significantly expressed and with a difference of mean expression above 3.7 are labelled with gene symbols.