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. 2019 Feb 28;9:3179. doi: 10.1038/s41598-019-39445-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predicted upstream regulators and gene expression of their regulomes. (A) Bar plot showing activation or inhibition scores of the upstream regulators. Transcription factors are highlighted in red. (B–F) Heat maps showing the expression profiles of the genes regulated by predicted transcription factors from A. Additional heat maps are shown in Supplementary Fig. S3. Samples in the HFpEF proxy group are coloured orange in Condition, and samples in the Normal physiology group are coloured green. The regulators genes were identified using IPA. Patient numbers and conditions are shown at the bottom of each heatmap.