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. 2019 Feb 28;9:3152. doi: 10.1038/s41598-019-39614-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time course of the BOLD response in the ipsilateral hippocampus. (a) Color coded ROIs (green: dentate gyrus (DG), purple: CA3, blue: molecular layer of DG (MoDG), yellow: radiatum layer of CA1 (CA1 Rad), and red: pyramidal layer of CA1 overlaid on the T2 weighted structural image. BOLD time courses in the entire ipsilateral hippocampus (b), CA1 Pyr (c), CA1 Rad (d), DG (e), CA3 (f), and MoDG (g) before and after LTP induction. The red boxes correspond to periods of electrical stimulation at the perforant pathway. The bar plots exhibit mean ± sem. ^*p < 0.05 (paired t-test). The interaction between BOLD time course and LTP effects (two-way repeated ANOVA) showed no significance.