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. 2019 Feb 28;9:3152. doi: 10.1038/s41598-019-39614-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BOLD response parameters in the ipsilateral hippocampus. The time to peak (a), time to baseline (b), peak intensity (c), area under the curve (d), and decay slope were measured using the same ROIs as in Fig. 4a. ^*p < 0.05 (paired t-test after versus before LTP at each region), ^bp < 0.05 (paired t-test Rad versus Pyr before LTP), and ^#p < 0.05 (paired t-test Rad versus Pyr 30 min after LTP). The integrated BOLD responses shown at CA1 Pyr (f), CA1 Rad (g), DG (h), CA3 (i), and MoDG (j) before and after LTP induction. The red boxes represent electrical stimulation periods at the perforant pathway. ^##p < 0.01, ^###p < 0.001 (LTP effect of the two-way repeated ANOVA). The bar plots exhibit mean ± sem.