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. 2019 Feb 22;51(2):22. doi: 10.1038/s12276-019-0215-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The types of data produced in this experiment are DNA methylation, mRNA expression, miRNA expression, and rare genetic variants. Differentially methylated regions (DMR) were separately investigated according to their sizes. The stretching ellipse represents the resolution of each type of DMRs identified. WGBS whole-genome bisulfite sequencing, PMD partially methylated domain, LMR low-methylated region, DMC differentially methylated CpG, DVC differentially variable CpG