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. 2019 Feb 28;9:3102. doi: 10.1038/s41598-019-39056-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlative Light Electron Microscopy (CLEM) confirms the presence of SAA in amyloidgenic fibrinogen clots. Purified fibrinogen was incubated with 30 μg.mL⁻¹ SAA, and marked with Amytracker 680 and fluorescent SAA antibody. (A–D) Fibrinogen clotted with thrombin. (A) Super-resolution micrograph combined with SEM micrograph using CLEM technology. (B) SEM micrograph. (C) Fluorescent SAA antibody micrograph. (D) Fluorescent Amytracker 680 micrograph. (E) SEM image of purified fibrinogen with SAA, but without thrombin (not clotted).