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. 2019 Feb 28;9:3123. doi: 10.1038/s41598-019-39781-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fibrillogenesis of the single mutants of the highly fibrillogenic peptide Ser26-Arg39 to proline (Scanning proline mutagenesis analysis). Panels (A,B) show the mean value plus the standard deviation of soluble fraction (blue squares) and ThT fluorescence (yellow circles) calculated from triplicates samples after (A) 16 hours and (B) 40 hours of incubation. Transmission electron micrographs of the aggregates formed by the point mutant peptides (C) Ser26Pro, (D) Ser27Pro, (E) Gly28Pro, (F) Ser29Pro, (G) Gln38Pro and (H) Arg39Pro. The scale bars represent 100 nm. The images were obtained with a HITACHI-7100 transmission electron microscope.