Table 2.
Pregnancy and neonatal outcomes stratified by ovarian stimulation protocolsa.
| Outcomes | Natural cycle (n = 4058) | Clomiphene alone (n = 4715) | Clomiphene + gonadotropin (n = 5443) | GnRH agonist (n = 16566) | GnRH antagonist (n = 7438) | P valueb |
|---|---|---|---|---|---|---|
| Pregnancy outcomes | ||||||
| Mode of delivery | ||||||
| Vaginal | 2732 (67.2) | 2963 (62.8) | 3357 (61.7) | 10791(65.1) | 4691 (63.1) | <0.001 |
| CS | 1100 (27.1) | 1463 (31.0) | 1501 (27.6) | 4294 (25.9) | 2022 (27.2) | |
| Unknown | 226 (5.6) | 289 (6.1) | 585 (10.8) | 1481 (8.9) | 725 (9.8) | |
| Neonatal outcomes | ||||||
| Gestational weeks at delivery, (weeks) | 38.8 (1.7) | 38.6 (1.9) | 38.6 (2.0) | 38.6 (1.9) | 38.6 (1.9) | <0.001 |
| ≧37 | 3658 (90.1) | 4185 (88.8) | 4467 (82.1) | 13844 (83.6) | 6127 (82.4) | <0.001 |
| 32–36 | 181 (4.5) | 287 (6.1) | 281 (5.2) | 987 (6.0) | 435 (5.9) | |
| <32 | 36 (0.89) | 50 (1.1) | 75 (1.4) | 157 (0.95) | 80 (1.1) | |
| Unknown | 183 (4.5) | 193 (4.1) | 620 (11.4) | 1578 (9.5) | 796 (10.7) | |
| Birthweight, (g) | 3008 (426) | 2928 (476) | 2927 (487) | 2950 (451) | 2954 (455) | <0.001 |
| ≧2500 | 3569 (87.8) | 3945 (83.4) | 4276 (78.6) | 13354 (80.6) | 5935 (79.8) | <0.001 |
| 1500–2499 | 303 (7.5) | 545 (11.6) | 585 (10.8) | 1634 (9.9) | 718 (9.7) | |
| <1500 | 28 (0.69) | 60 (1.3) | 93 (1.7) | 168 (1.0) | 78 (1.1) | |
| Unknown | 158 (3.9) | 165 (3.5) | 489 (9.0) | 1410 (8.5) | 707 (9.5) | |
| Sex of neonates | ||||||
| Male | 1962 (48.4) | 2300 (48.8) | 2494 (45.8) | 7877 (47.6) | 3453 (46.4) | 0.19 |
| Female | 1939 (47.8) | 2253 (47.8) | 2465 (45.3) | 7323 (44.2) | 3278 (44.1) | |
| Unknown | 157 (3.9) | 162 (3.4) | 484 (8.9) | 1366 (8.3) | 707 (9.5) | |
| (n = 3851) | (n = 4508) | (n = 4764) | (n = 14823) | (n = 6571) | ||
| SGAc | 208 (5.4) | 397 (8.8) | 450 (9.5) | 998 (6.7) | 455 (6.9) | <0.001 |
| LGAc | 380 (9.9) | 400 (8.9) | 411 (8.6) | 1350 (9.1) | 619 (9.4) | 0.29 |
aData are presented as mean (SD) for continuous variables and n (%) for dichotomous variables.
bP values were assessed with the use of χ2 test excluding missing values or one-way analysis of variance.
cSGA was defined as being below the 10th percentile of the national reference. LGA was defined as being above the 10th percentile of the national reference. Denominators are neonatal outcomes without unknown gestational week at delivery, birth weight, sex of neonates, and over 42 weeks at gestation.
CS, cesarean section; SGA, small for gestational age; LGA, large for gestational age.