Table 5.
Crude and adjusted ORs of ovarian stimulation using clomiphene citrate compared with natural cycle for pregnancy and neonatal outcomes among subgroup of one oocyte retrieval.
| Outcomes | Cycles with one oocyte retrieval | |||||
|---|---|---|---|---|---|---|
| Crude OR (95% Cl) | Adjusted OR (95% Cl)a | |||||
| Natural cycle | Clomiphene alone | P value | Natural cycle | Clomiphene alone | P value | |
| PTD (<37 weeks) | Reference | 1.34 (1.09 to 1.65) | 0.006 | Reference | 1.33 (1.06 to 1.66) | 0.01 |
| VPTD (<32 weeks) | Reference | 0.91 (0.53 to 1.56) | 0.73 | Reference | 0.85 (0.47 to 1.54) | 0.59 |
| LBW (<2500 g) | Reference | 1.50 (1.18 to 1.91) | 0.001 | Reference | 1.44 (1.11 to 1.89) | 0.01 |
| VLBW (<1500 g) | Reference | 1.40 (0.87 to 2.27) | 0.17 | Reference | 1.35 (0.79 to 2.30) | 0.27 |
| SGA b | Reference | 1.69 (1.34 to 2.14) | <0.001 | Reference | 1.68 (1.30 to 2.18) | <0.001 |
| LGA b | Reference | 1.00 (0.86 to 1.17) | 0.97 | Reference | 0.99 (0.87 to 1.13) | 0.93 |
| CS | Reference | 1.28 (1.17 to 1.41) | <0.001 | Reference | 1.22 (1.07 to 1.39) | 0.003 |
aAdjusted for maternal age, infertility diagnosis, fertilization method, fetal sex and year.
bSGA was defined as being below the 10th percentile of the national reference. LGA was defined as being above the 10th percentile of the national reference.
CI, confidence interval; CS, cesarean section; LBW, low birth weight; LGA, large for gestational age; OR, odds ratio; PTD, preterm delivery; SGA, small for gestational age; VLBW, very low birth weight; VPTD, very preterm delivery.