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. 2019 Feb 28;9:3154. doi: 10.1038/s41598-019-39102-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ang-(1-7) treatment for 7 days significantly attenuates lesion growth from 60 min MCAO lesion. (a) Ischaemic lesion evolution from 60 min MCAO (prior to therapy) to 7 days post MCAO along with therapy for each individual animal in both vehicle (1 μl/hr aCSF; n = 13) and Ang-(1-7) (1.1 nmol/hr; n = 13) treated groups. Ischaemic lesion and reperfusion extent varies amongst rats. (b,c) Ang-(1-7) ICV therapy along with reperfusion significantly decreases ischaemic lesion evolution from 60 min MCAO to 7 days post MCAO compared to vehicle. (d) Therapy effects are independent of systolic BP induced alterations from pre to 7 days post MCAO (n = 12–13 per group). (e,f) Final infarct volume or neurological score evaluated at day 7 only did not differ amongst groups (n = 13 per group). Data are presented as mean ± S.D; **P < 0.01; ***P < 0.001; unpaired Student’s t test.