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. 2019 Feb 28;9:3154. doi: 10.1038/s41598-019-39102-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ang-(1-7) does not influence BBB breakdown 24 hr post MCAO. (a,b) Gd-DTPA enhancement volume across the ipsilateral hemisphere did not differ between Ang-(1-7) (1.1 nmol/hr; n = 11) and control rats (aCSF; n = 12). (c) Ang-(1-7) therapy (n = 15) did not alter hemispheric swelling volume compared to Vehicle (aCSF; n = 13). (d) Gene expression levels for BBB breakdown marker, Mmp9, were significantly upregulated in MCAO vehicle group (n = 7) and nearly reaching significance in Ang-(1-7) treated rats (n = 7) compared to sham rats (n = 6). Ang-(1-7) did not alter Mmp9 mRNA levels compared to vehicle treated rats. (e) Gene expression values for Mmp9 inhibitor, Timp1, were significantly upregulated in MCAO groups (n = 7 per group) compared to sham animals (n = 6) without Ang-(1-7) induced effects compared to control. (f,g) Ang-(1-7) ICV therapy (n = 15) for 24 hr did not alter infarct volume in comparison to vehicle treated rats (n = 13). Data are presented as mean ± S.D. *P < 0.05; ***P < 0.001; unpaired Student’s t test. Gene expression data were compared using one-way ANOVA with Tukey’s posthoc test; *P < 0.05; ***P < 0.001 compared to sham.