Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 28;9:3154. doi: 10.1038/s41598-019-39102-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Ang-(1-7) significantly attenuates Nox1 gene expression to sham levels 7 days post MCAO in peri-infarct regions. (a) Nox1 was comparable to sham at 24 hr for MCAO-Vehicle and MCAO-Ang-(1-7) treated groups. Conversely, at 7 days post MCAO, Nox1 was significantly decreased in MCAO-Vehicle group with Ang-(1-7) treatment attenuating the expression to sham levels (P < 0.05). (b) Nox2 expression did not alter at 24 hr or 7 days post MCAO when compared to sham. (c–h) Il1b, Il6, Nos2, Itgam, Ptgs2 or Nfkb1 expression was not influenced by Ang-(1-7) therapy at 24 hr and 7 days post MCAO. Data displays values for sham (n = 6–7); MCAO-Vehicle (aCSF) (n = 7–9) and MCAO-Ang-(1-7) (n = 7–9) treated rats. Data are presented as mean ± S.D. *P < 0.05 compared to sham; ^#P < 0.05 compared to MCAO-Vehicle; one-way ANOVA with Tukey’s posthoc test.