Fig. 1.

Chromosome 11p15 locus. A: Black bar represents the amplicon generated for Pyrosequencing®. CpG sites analysed are numbered and shown as black triangles. The grey bar represents the location of the Pyrosequencing® primer. Location of rs231840 is shown. B: Topography of region of interest. Gene annotations were taken from the University of California Santa Cruz genome browser (http://genome.ucsc.edu/). C: Linkage disequilibrium plot created from Haploview v4.2. Values indicated are D′ (1 = complete linkage disequilibrium). Colour scheme represents r² values: r² = 0, white; 0 < r² < 1, shades of grey; r² = 1, black. Grey squares around SNP identifiers indicate the blocks as defined by solid spine linkage disequilibrium (SSLD) or singleton SNPs. Type 2 diabetes associated SNPs are shown at top of the panel (rs2334499, rs231362, rs2237892).