Table 1.
RISC cohort characteristics.
| Characteristic | Sub-group median (IQR) | Remaining cohort median (IQR) | P value (Mann-Whitney) |
|---|---|---|---|
| N | 510 | 809 | |
| Age (years) | 45 (38–51) | 43 (36–49) | 1.420e−04 |
| Men (%)* | 44.9 | 44.2 | 0.806 |
| BMI (kg/m2) | 24.8 (23.0–27.7) | 25.1 (22.6–27.8) | 0.788 |
| Fasting glucose (mmol/l)† | 5.2 (4.8–5.5) | 5.0 (4.7–5.4) | 1.565e−06 |
| 2 h glucose (mmol/l)† | 5.7 (4.9–6.7) | 5.7 (4.6–6.6) | 0.033 |
| Fasting Insulin (mU/L) | 4.5 (2.8–6.2) | 4.5 (3.0–6.5) | 0.895 |
| M value (μmol/min/kgffm) | 53.3 (39.6–66.8) | 51.8 (38.7–64.7) | 0.206 |
| Adiponectin (μg/ml) | 7.7 (5.6–10.0) | 7.8 (5.5–10.7) | 0.388 |
| Leptin (ng/ml) | 9.5 (2.7–16.3) | 10.0 (4.7–17.9) | 0.716 |
| Β-cell glucose sensitivity (pmol/min/m2/(mmol/l) | 112.6 (76.5–154.8) | 113.5 (79.2–162.1) | 0.665 |
| HOMA-IR | 1.0 (0.6–1.4) | 1.0 (0.6–1.5) | 0.448 |
*
Fishers exact test.
†
Measured by Oral Glucose Tolerance Test. IQR: Inter-quartile range. Sub-group represents samples for which methylation data was generated. Remaining cohort represents remaining samples from the study population (total n = 1319) ffm, fat-free mass.