Table 2.
SNP regression analysis.
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| Measure | SNP | r2 value for LD between SNP and rs231840 | Coefficient (95% confidence interval) | p value | Coefficient (95% confidence interval) | p value |
| M value (μmol/min/kgffm) | rs2334499 | 0.00 | 1.02 (0.98, 1.06) | 0.341 | 1.01 (0.98, 1.05) | 0.398 |
| rs3817198 | 0.00 | 1.03 (1.00, 1.07) | 0.086 | 1.02 (0.99, 1.06) | 0.145 | |
| rs231362 | 0.18 | 0.97 (0.93, 1.00) | 0.048 | 0.98 (0.95, 1.01) | 0.228 | |
| rs7105073 | 0.02 | 0.98 (0.91, 1.05) | 0.560 | 1.01 (0.95, 1.07) | 0.694 | |
| rs7128926 | 0.06 | 0.99 (0.94, 1.03) | 0.504 | 1.00 (0.96, 1.04) | 0.979 | |
| rs7941377 | 0.03 | 1.02 (0.95, 1.10) | 0.619 | 1.01 (0.95, 1.08) | 0.673 | |
| rs231357 | 0.41 | 0.94 (0.91, 0.97) | 3.841 e−04 | 0.96 (0.93, 0.99) | 0.004 | |
| rs11023793 | 0.05 | 0.98 (0.94, 1.02) | 0.317 | 0.99 (0.95, 1.02) | 0.444 | |
| rs16928561 | 0.02 | 0.92 (0.86, 0.99) | 0.033 | 0.97 (0.91, 1.03) | 0.303 | |
| rs7927129 | 0.05 | 0.98 (0.93, 1.02) | 0.319 | 0.99 (0.95, 1.03) | 0.655 | |
| rs11023831 | 0.02 | 0.96 (0.89, 1.03) | 0.275 | 0.99 (0.93, 1.06) | 0.759 | |
| rs462402 | 0.38 | 1.06 (1.02, 1.09) | 0.001 | 1.04 (1.01, 1.07) | 0.013 | |
| rs463924 | 0.89 | 0.95 (0.92, 0.99) | 0.014 | 0.97 (0.93, 1.00) | 0.035 | |
| rs231841 | 0.77 | 0.95 (0.91, 0.98) | 0.002 | 0.97 (0.94, 1.00) | 0.025 | |
| rs231840 | – | 0.95 (0.91, 0.98) | 0.004 | 0.97 (0.94, 1.00) | 0.076 | |
| rs2283197 | 0.79 | 0.95 (0.92, 0.99) | 0.011 | 0.97 (0.94, 1.00) | 0.086 | |
| rs2283200 | 0.03 | 1.03 (0.95, 1.10) | 0.502 | 1.02 (0.95, 1.08) | 0.618 | |
| rs231901 | 0.02 | 0.96 (0.91, 1.01) | 0.154 | 0.98 (0.93, 1.03) | 0.369 | |
| rs4930149 | 0.03 | 0.98 (0.92, 1.04) | 0.506 | 0.99 (0.94, 1.04) | 0.616 | |
| rs2237892 | 0.00 | 0.95 (0.89, 1.02) | 0.147 | 0.94 (0.89, 0.99) | 0.031 | |
| Adiponectin (μg/ml) | rs2334499 | 0.00 | 1.00 (0.97, 1.04) | 0.818 | 1.01 (0.98, 1.04) | 0.685 |
| rs3817198 | 0.00 | 1.00 (0.96, 1.04) | 0.887 | 1.00 (0.96, 1.03) | 0.784 | |
| rs231362 | 0.18 | 0.97 (0.94, 1.01) | 0.129 | 0.97 (0.94, 1.00) | 0.064 | |
| rs7105073 | 0.02 | 0.96 (0.89, 1.03) | 0.265 | 0.99 (0.93, 1.05) | 0.685 | |
| rs7128926 | 0.06 | 0.97 (0.93, 1.02) | 0.258 | 0.99 (0.95, 1.03) | 0.578 | |
| rs7941377 | 0.03 | 0.96 (0.89, 0.04) | 0.302 | 0.97 (0.91, 1.04) | 0.410 | |
| rs231357 | 0.41 | 0.95 (0.92, 0.99) | 0.007 | 0.96 (0.93, 0.98) | 0.002 | |
| rs11023793 | 0.05 | 0.99 (0.95, 1.04) | 0.721 | 1.00 (0.96, 1.04) | 0.976 | |
| rs16928561 | 0.02 | 0.93 (0.86, 1.00) | 0.055 | 0.98 (0.92, 1.04) | 0.502 | |
| rs7927129 | 0.05 | 0.97 (0.92, 1.01) | 0.170 | 0.99 (0.95, 1.03) | 0.755 | |
| rs11023831 | 0.02 | 0.95 (0.88, 1.03) | 0.209 | 0.97 (0.91, 1.04) | 0.396 | |
| rs462402 | 0.38 | 1.04 (1.00, 1.08) | 0.033 | 1.04 (1.01, 1.07) | 0.017 | |
| rs463924 | 0.89 | 0.98 (0.94, 1.02) | 0.363 | 0.97 (0.94, 1.00) | 0.070 | |
| rs231841 | 0.77 | 0.98 (0.95, 1.02) | 0.379 | 0.98 (0.95, 1.01) | 0.164 | |
| rs231840 | – | 0.97 (0.93, 1.01) | 0.175 | 0.97 (0.94, 1.01) | 0.096 | |
| rs2283197 | 0.79 | 0.97 (0.94, 1.01) | 0.130 | 0.97 (0.94, 1.00) | 0.076 | |
| rs2283200 | 0.03 | 0.95 (0.88, 1.02) | 0.186 | 0.96 (0.90, 1.02) | 0.146 | |
| rs231901 | 0.02 | 0.96 (0.91, 1.02) | 0.178 | 0.99 (0.94, 1.03) | 0.540 | |
| rs4930149 | 0.03 | 0.98 (0.93, 1.05) | 0.603 | 0.99 (0.94, 1.05) | 0.816 | |
| rs2237892 | 0.00 | 0.98 (0.92, 1.05) | 0.621 | 0.98 (0.92, 1.04) | 0.448 | |
Regression analysis of neighbouring SNP genotypes predicting metabolic measures M and adiponectin for the genotyped RISC cohort (n = 1119). Table shows unadjusted analyses and adjusted for confounders. Regression analysis outcomes are presented as: (exponent of regression coefficient (95% confidence interval), p-value). ffm, fat-free mass.