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. 2019 Feb 14;22:101117. doi: 10.1016/j.redox.2019.101117

Fig. 9.

Fig. 9

Blockage of HSP60 alleviated MCT-induced HSOS in mice. (A) Serum ALT/AST activity (n = 5). (B) Liver MPO activity (n = 5). (C) Liver histological evaluation (n = 3). (original magnification, 100× and 200×). The arrows indicate intrahepatic hemorrhage, indicate necrosis of hepatocytes, indicate hepatic infiltration of immune cells. (D) Liver scanning electron microscopy evaluation (n = 3). (original magnification, 20,000 ×). Red arrows indicate the enlargement of fenestrate, exposure of the Disse space and the damage of endothelium. (a) Control. (b) 360 mg/kg MCT. (c) 360 mg/kg MCT + anti-HSP60 antibody. (d) 360 mg/kg MCT + IgG. (E) Liver expression of TLR4 and nuclear NFκBp65. (F) The quantitative densitometric analysis of TLR4 and nuclear NFκBp65 (n = 4). Data are expressed as mean ± SEM. *P < 0.01, **P < 0.01, ***P < 0.001versus control. #P < 0.05, ##P < 0.01, ###P < 0.001 versus MCT.