TABLE 1.
Antimicrobial activity of omadacycline tested against the main organisms and organism groups of isolates from all countries combined
| Organism or organism group (no. of isolates) | No. (cumulative %) of isolates at an MIC (mg/liter) of: |
MIC50 (mg/liter) | MIC90 (mg/liter) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | |||
| Staphylococcus aureus (689) | 1 (0.1) | 39 (5.8) | 487 (76.5) | 117 (93.5) | 35 (98.5) | 10 (100.0) | 0.12 | 0.25 | ||||||
| Methicillin susceptible (390) | 0 (0.0) | 23 (5.9) | 333 (91.3) | 32 (99.5) | 2 (100.0) | 0.12 | 0.12 | |||||||
| Methicillin resistant (299) | 1 (0.3) | 16 (5.7) | 154 (57.2) | 85 (85.6) | 33 (96.7) | 10 (100.0) | 0.12 | 0.5 | ||||||
| Tetracycline resistant (317) | 17 (5.45) | 182 (62.8) | 77 (87.1) | 32 (97.2) | 9 (100.0) | 0.12 | 0.5 | |||||||
| Doxycycline resistant (33) | 9 (27.3) | 10 (57.6) | 10 (87.9) | 4 (100.0) | 0.25 | 1 | ||||||||
| Enterococcus spp. (103) | 15 (14.6) | 54 (67.0) | 28 (94.2) | 5 (99.0) | 1 (100.0) | 0.06 | 0.12 | |||||||
| Vancomycin nonsusceptible (>4 mg/liter; 13) | 2 (15.45) | 9 (84.6) | 2 (100.0) | 0.06 | 0.12 | |||||||||
| Enterococcus faecalis (48) | 5 (10.4) | 19 (50.0) | 18 (87.5) | 5 (97.9) | 1 (100.0) | 0.06 | 0.25 | |||||||
| Enterococcus faecium (52) | 10 (19.2) | 32 (80.8) | 10 (100.0) | 0.06 | 0.12 | |||||||||
| Streptococcus pneumoniae (392) | 20 (5.1) | 233 (64.5) | 134 (98.7) | 5 (100.0) | 0.06 | 0.12 | ||||||||
| Penicillin resistant, oral (≥2 mg/liter; 211) | 6 (2.8) | 125 (62.1) | 77 (98.6) | 3 (100.0) | 0.06 | 0.12 | ||||||||
| Tetracycline resistant (359) | 14 (3.9) | 209 (62.1) | 131 (98.6) | 5 (100.0) | 0.12 | 0.5 | ||||||||
| Tigecycline nonsusceptible (36) | 2 (5.6) | 31 (91.7) | 36 (100.0) | 0.25 | 1 | |||||||||
| Viridans group streptococci (94) | 20 (21.3) | 53 (77.7) | 15 (93.6) | 6 (100.0) | 0.06 | 0.12 | ||||||||
| β-Hemolytic streptococci (166) | 0 (0.0) | 36 (21.7) | 76 (67.5) | 38 (90.4) | 14 (98.8) | 2 (100.0) | 0.12 | 0.25 | ||||||
| Enterobacteriaceae (1,041) | 0 (0.0) | 8 (0.8) | 137 (13.9) | 357 (48.2) | 277 (74.8) | 146 (88.9) | 47 (93.4) | 44 (97.6) | 21 (99.6) | 4 (100.00) | 2 | 8 | ||
| Escherichia coli (425) | 0 (0.0) | 7 (1.6) | 124 (30.8) | 180 (73.2) | 86 (93.4) | 23 (98.8) | 3 (99.5) | 2 (100.0) | 1 | 2 | ||||
| ESBL phenotype (249) | 0 (0.0) | 5 (2.0) | 70 (30.1) | 104 (71.9) | 50 (92.0) | 15 (98.0) | 3 (99.2) | 2 (100.0) | 1 | 2 | ||||
| Klebsiella pneumoniae (307) | 0 (0.0) | 1 (0.3) | 11 (3.9) | 114 (41.0) | 91 (70.7) | 54 (88.3) | 20 (94.8) | 12 (98.7) | 3 (99.7) | 1 (100.0) | 2 | 8 | ||
| ESBL phenotype (134) | 0 (0.0) | 2 (1.5) | 33 (26.1) | 37 (53.7) | 37 (81.3) | 14 (91.8) | 9 (98.5) | 1 (99.3) | 1 (100.0) | 2 | 8 | |||
| Klebsiella oxytoca (16) | 0 (0.0) | 10 (62.5) | 2 (75.0) | 3 (93.8) | 1 (100.0) | 1 | 4 | |||||||
| Enterobacter cloacae species complex (110) | 0 (0.0) | 23 (20.9) | 59 (74.5) | 18 (90.9) | 5 (95.5) | 3 (98.2) | 2 (100.0) | 2 | 4 | |||||
| Ceftazidime nonsusceptible (>4 mg/liter; 52) | 0 (0.0) | 6 (11.5) | 26 (61.5) | 12 (84.6) | 5 (94.2) | 2 (98.1) | 1 (100.0) | 2 | 8 | |||||
| Serratia marcescens (46) | 0 (0.0) | 12 (26.1) | 33 (97.8) | 1 (100.0) | 4 | 4 | ||||||||
| Acinetobacter baumannii (225) | 0 (0.0) | 2 (0.9) | 24 (11.6) | 6 (14.2) | 1 (14.7) | 9 (18.7) | 90 (58.7) | 81 (94.7) | 7 (97.8) | 4 (99.6) | 1 (100.0) | 4 | 8 | |
| Pseudomonas aeruginosa (300) | 0 (0.0) | 4 (1.3) | 2 (2.0) | 20 (8.7) | 121 (49.0) | 153 (100.0) | >32 | >32 | ||||||
| Haemophilus influenzae (181) | 0 (0.0) | 12 (6.6) | 88 (55.2) | 69 (93.4) | 12 (100.0) | 0.5 | 1 | |||||||
| β-Lactamase positive (69) | 0 (0.0) | 35 (50.7) | 29 (92.8) | 5 (100.0) | 0.5 | 1 | ||||||||
| Haemophilus parainfluenzae (7) | 0 (0.0) | 1 (14.3) | 6 (100.0) | 1 | ||||||||||
| Moraxella catarrhalis (75) | 57 (76.0) | 18 (100.0) | ≤0.12 | 0.25 | ||||||||||