TABLE 2.
Summary of omadacycline activity stratified by geographic regiona
| Organism | Omadacycline MIC50/MIC90 (mg/liter) of strains from: |
||
|---|---|---|---|
| China | Hong Kong | Taiwan | |
| S. aureus | 0.12/0.25 | 0.12/0.25 | 0.12/0.25 |
| MSSA | 0.12/0.12 | 0.12/0.12 | 0.12/0.12 |
| MRSA | 0.25/0.5 | 0.12/0.25 | 0.12/0.25 |
| S. pneumoniae | 0.06/0.12 | 0.06/0.12 | 0.06/0.12 |
| Penicillin S (MIC, ≤0.06 mg/liter)b | 0.06/0.12 | 0.06/0.12 | 0.06/ND |
| Penicillin I (MIC, 0.12–1 mg/liter)b | 0.06/0.12 | 0.06/ND | 0.06/0.12 |
| Penicillin R (MIC, ≥2 mg/liter)b | 0.06/0.12 | 0.06/0.12 | 0.12/0.12 |
| β-Hemolytic streptococci | 0.12/0.25 | 0.12/0.5 | 0.12/0.5 |
| Viridans group streptococci | 0.06/0.12 | 0.06/0.25 | 0.06/0.12 |
| Enterococcus faecalis | 0.06/0.25 | 0.12/ND | 0.12/ND |
| Enterococcus faecium | 0.06/0.12 | 0.06/ND | 0.06/0.12 |
| Vancomycin NS (MIC, ≥8 mg/liter) | 0.06/ND | 0.06/ND | 006/ND |
| H. influenzae | 0.5/1 | 1/1 | 0.5/1 |
| M. catarrhalis | ≤0.12/0.25 | ≤0.12/0.25 | ≤0.12/0.25 |
| Enterobacteriaceae | 1/4 | 2/16 | 2/8 |
| E. coli | 1/2 | 1/2 | 1/2 |
| ESBL phenotype | 1/2 | 1/2 | 1/4 |
| K. pneumoniae | 2/4 | 2/8 | 2/8 |
| ESBL phenotype | 2/8 | 2/ND | 2/16 |
| E. cloacae | 2/8 | 2/ND | 2/4 |
| Citrobacter spp. | 2/8 | 1/ND | 1/ND |
| P. mirabilis | 16/32 | 16/32 | 16/ND |
| Indole-positive Proteus spp. | 4/16 | 8/ND | |
| S. marcescens | 4/4 | 4/4 | 4/ND |
| A. baumannii | 4/8 | 4/32 | 4/8 |
| P. aeruginosa | >32/>32 | >32/>32 | >32/>32 |
a
MSSA, methicillin-susceptible S. aureus; MRSA, methicillin-resistant S. aureus; S, susceptible; I, intermediate; R, resistant; NS, nonsusceptible; ESBL, extended-spectrum β-lactamase; ND, not determinate due to less than 10 isolates within the group.
b
Using oral breakpoints (26).