FIG 4.
In vivo dose response of murepavadin against three P. aeruginosa isolates in the neutropenic murine lung infection model. (A) P. aeruginosa ATCC 27853. (B) NCTC 13437. (C) Isolate 16. Each symbol represents a therapy response in one mouse lung. The x axis is the murepavadin exposure expressed as AUC of the unbound fraction of the drug from 0 to 24 h (fAUC0–24 h). The y axis is the change in log10 of bacterial burden from the start of treatment. (A) The results from the study conducted at Radboud University are indicated with a blue triangle, and those from the study conducted at Evotec (UK) Ltd. are indicated with a black dot. The ED50 represents the AUC associated with 50% of the maximal effect (Emax). The line is the best fit based on the sigmoid Emax model.