. 2019 Feb 26;63(3):e01699-18. doi: 10.1128/AAC.01699-18

TABLE 2.

Pharmacokinetic parameter estimates for murepavadin in plasma of neutropenic mice following s.c. administration

Pharmacokinetic parameter^a	Value for model at a dose (mg/kg) of:
Pharmacokinetic parameter^a	0.125 (thigh)	0.25 (lung)	0.5 (thigh)	1 (lung)	2 (thigh)	4 (lung)	8 (thigh)	16 (lung)
T_max (h)	0.3	0.3	0.5	0.3	0.3	0.5	0.5	0.8
C_max (ng/ml)	175	319	650	1,470	2,460	4,400	5,820	12,600
T_last (h)	2	2	8	8	12	12	12	12
C_last (ng/ml)	41.2	58.8	12.6	10.6	24.5	21.2	54.2	144
AUC_last (h ng/ml)	186	349	922	1,570	3,860	6,100	13,400	30,000
AUC_INF (h ng/ml)	234	403	946	1,580	3,920	6,210	13,500	30,400
CL/F (ml/h/kg)	533	620	529	632	511	644	592	527
V_z/F (ml/kg)	622	566	1,000	947	1,160	3,520	1,400	1,230
t_1/2 (h)	0.8	0.6	1.3	1	1.6	3.8	1.6	1.6
R²	0.997	0.992	0.918	0.919	0.86	0.986	0.954	0.916

T_last, time of last quantifiable concentration; C_last, last quantifiable concentration; AUC_INF, AUC to infinity; CL/F, apparent total clearance of drug after oral administration; V_z/F, apparent volume of distribution during terminal phase after oral administration; t_1/2, half-life.