TABLE 3.
Penetration of murepavadin in ELF
| Dose (mg/kg) | Values by sample type |
|||||
|---|---|---|---|---|---|---|
| ELF |
Plasma |
ELF/fplasmaa |
||||
| Cmax (mg/liter) | AUC (h mg/liter) | fCmax (mg/liter) | fAUC (h mg/liter) | Cmax (%) | AUC (%) | |
| 0.125 | 0.088 | 0.02 | 0.0392 | 0.042 | 224.5 | 48 |
| 0.25 | 0.095 | 0.055 | 0.0715 | 0.078 | 132.9 | 70.4 |
| 0.5 | 0.169 | 0.133 | 0.146 | 0.207 | 115.8 | 64.4 |
| 1 | 0.336 | 0.296 | 0.329 | 0.352 | 102.1 | 84.2 |
| 2 | 1.37 | 1.455 | 0.551 | 0.865 | 248.6 | 168.3 |
| 4 | 0.726 | 1.795 | 0.986 | 1.366 | 73.6 | 131.4 |
| 8 | 1.43 | 4.239 | 1.304 | 3.002 | 109.7 | 141.2 |
| 16 | 4.76 | 14.001 | 2.82 | 6.72 | 168.7 | 208.3 |
a
Values for ELF/fplasma (ratio of ELF exposure to free plasma exposure expressed as percent) Cmax (%) and AUC (%) were geometric mean, 136.3 and 102.2; mean, 147.0 and 114.5; and SD, 31.4 and 56.7, respectively.