FIG 2.

P. falciparum asexual-stage growth reduction rate assay. P. falciparum 3D7-infected erythrocytes were treated with compound (10× EC₅₀ in Table 1, as determined by the hypoxanthine assay) for 24 or 48 h, after which the compound was washed out and the parasites were grown for another 48 h. Parasite viability was quantified by flow cytometry and is shown as the percentage of infected CFDA-SE-stained erythrocytes in drug-treated samples at 24 or 48 h using vehicle-treated parasites as a reference (100% parasitemia).