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. 2019 Feb 26;63(3):e01804-18. doi: 10.1128/AAC.01804-18

TABLE 1.

Evaluation of compounds against P. falciparum 3D7 and P. knowlesi YH1 parasites

Compound Mean (SD) EC50 (μM)
P. falciparum LDHa P. falciparum hypoxanthineb Flow cytometryc
P. falciparum P. knowlesi
1 0.079 (0.030) 0.081 (0.011) 0.087 (0.001) 0.065 (0.007)
2 0.121 (0.009) 0.073 (0.008) 0.081 (0.011) 0.059 (0.010)
3 0.074 (0.021) NDd 0.088 (0.002) 0.065 (0.011)
4 0.090 (0.004) 0.118 (0.024) 0.110 (0.037) 0.095 (0.008)
Chloroquine 0.017 (0.001) 0.034 (0.002) 0.053 (0.007) 0.038 (0.008)
Mefloquine 0.011 (0.005) ND 0.018 (0.004) 0.003 (0.001)
a

Growth was quantified by lactate dehydrogenase (LDH) activity after 72 h of treatment.

b

Proliferation was quantified by [3H]hypoxanthine incorporation after 72 h of treatment.

c

Growth was quantified by flow cytometry using SYBR green-stained asexual-stage parasites of P. falciparum 3D7 (72 h) or P. knowlesi YH1 (48 h).

d

ND, not determined.