TABLE 1.
Compound | Mean (SD) EC50 (μM) |
|||
---|---|---|---|---|
P. falciparum LDHa | P. falciparum hypoxanthineb |
Flow cytometryc
|
||
P. falciparum | P. knowlesi | |||
1 | 0.079 (0.030) | 0.081 (0.011) | 0.087 (0.001) | 0.065 (0.007) |
2 | 0.121 (0.009) | 0.073 (0.008) | 0.081 (0.011) | 0.059 (0.010) |
3 | 0.074 (0.021) | NDd | 0.088 (0.002) | 0.065 (0.011) |
4 | 0.090 (0.004) | 0.118 (0.024) | 0.110 (0.037) | 0.095 (0.008) |
Chloroquine | 0.017 (0.001) | 0.034 (0.002) | 0.053 (0.007) | 0.038 (0.008) |
Mefloquine | 0.011 (0.005) | ND | 0.018 (0.004) | 0.003 (0.001) |
Growth was quantified by lactate dehydrogenase (LDH) activity after 72 h of treatment.
Proliferation was quantified by [3H]hypoxanthine incorporation after 72 h of treatment.
Growth was quantified by flow cytometry using SYBR green-stained asexual-stage parasites of P. falciparum 3D7 (72 h) or P. knowlesi YH1 (48 h).
ND, not determined.