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. 2019 Feb 26;63(3):e02404-18. doi: 10.1128/AAC.02404-18

TABLE 1.

Study organisms, KBP-7072 susceptibility results, and in vivo fitness

Species Strain MIC (mg/liter)
Control growth (log10 CFU/lung) Comment
KBP-7072 Minocycline
S. aureus ATCC 33591 0.25 8 2.05 MRSA
ATCC 25923 0.25 0.125 1.80 MSSA
ATCC 29213 0.25 0.06 1.62 MSSA
MW2 0.25 2 1.60 MRSA
R2527 0.25 2 2.55 MRSA
S. pneumoniae ATCC 10813 0.016 0.03 2.73 Wild type
1293 0.016 2 2.35 Penr Tetr
1199 0.016 4 1.81 Tetr
140 0.016 0.016 1.97 Pens
673 0.008 0.004 1.62 Penr
1285 0.016 0.03 2.01 Peni