TABLE 2.

Pharmacodynamic targets associated with net stasis, 1-log kill, and 2-log kill in the neutropenic murine pneumonia infection model for S. aureus and S. pneumoniae^a

Species	Strain	Stasis				1-log kill				2-log kill
		24-h dose (mg/kg)	24-h plasma tAUC/MIC	24-h plasma fAUC/MIC	24-h ELF AUC/MIC	24-h dose (mg/kg)	24-h plasma tAUC/MIC	24-h plasma fAUC/MIC	24-h ELF AUC/MIC	24-h dose (mg/kg)	24-h plasma tAUC/MIC	24-h plasma fAUC/MIC	24-h ELF AUC/MIC
S. aureus	ATCC 33591	1.78	6.54	1.47	2.62	5.54	22.21	5.00	6.97	18.17	80.25	18.06	17.91
	ATCC 25923	1.05	3.84	0.86	1.54	1.59	5.84	1.31	2.34	2.38	8.74	1.97	3.49
	ATCC 29213	1.17	4.31	0.97	1.72	3.22	11.81	2.66	4.72	7.86	33.61	7.56	8.64
	MW2	1.09	3.99	0.90	1.60	1.79	6.56	1.48	2.63	2.91	10.67	2.40	4.27
	R2527	1.77	6.49	1.46	2.60	3.01	11.04	2.48	4.41	6.28	25.84	5.81	7.51
	Mean	1.37	5.04	1.13	2.01	3.03	11.49	2.59	4.22	7.52	31.82	7.16	8.37
	Median	1.17	4.31	0.97	1.72	3.01	11.04	2.48	4.41	6.28	25.84	5.81	7.51
	SD	0.37	1.36	0.31	0.55	1.58	6.54	1.47	1.87	6.38	29.00	6.53	5.75
S. pneumoniae	ATCC 10813	0.11	6.28	1.41	2.51	0.30	16.96	3.82	6.78	0.81	46.50	10.46	18.60
	1293	0.06	3.54	0.80	1.42	0.21	12.31	2.77	4.92	0.70	40.05	9.01	16.02
	1199	0.19	11.09	2.50	4.44	1.04	59.87	13.47	23.95	7.84	523.67	117.83	134.83
	140	0.04	2.46	0.55	0.98	0.18	10.46	2.35	4.18	0.73	42.08	9.47	16.83
	673	0.09	10.50	2.36	4.20	0.31	35.85	8.07	14.34	0.95	108.45	24.40	43.38
	1285	0.06	3.65	0.82	1.46	0.27	15.73	3.54	6.29	1.21	69.62	15.67	27.85
	Mean	0.09	6.25	1.41	2.50	0.39	25.20	5.67	10.08	2.04	138.40	31.14	42.92
	Median	0.08	4.97	1.12	1.99	0.28	16.34	3.68	6.54	0.88	58.06	13.06	23.22
	SD	0.05	3.74	0.84	1.50	0.33	19.27	4.34	7.71	2.85	190.50	42.86	46.20

^atAUC, total drug AUC; fAUC, free drug AUC; ELF, epithelial lining fluid. Means, medians, and SDs are in bold.