TABLE 2.
MIC results for a subset of the test compounds and triclosan against human mycoplasma type strains M. genitalium, M. hominis ATCC 23411, and U. urealyticum ATCC 33175e
| Organism | MIC (µM) for the following compounds: |
QC drug MIC (µg/ml) |
No. (%) of AMCs with MICs of ≤12.5 µM | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | 10 | 11 | 12 | 14 | 15 | 19 | 20 | 21 | 22 | Triclosan | Levofloxacin | Tetracycline | ||
| M. genitaliuma | NA | 12.5 | NA | 12.5 | >12.5 | 12.5 | 12.5 | >12.5 | 3.13 | NA | 120 | 1 | 5 (71.4) | |
| M. pneumoniaeb | >12.5 | 12.5 | >12.5 | 12.5 | 6.25 | 6.25 | 6.25 | 2.35c | 3.13 | 3.13 | 60 | 0.5 | 8 (80) | |
| U. urealyticumb | >12.5 | 12.5 | >12.5 | 3.13 | >25 | >25 | >25 | 25 | >25 | NA | >120 | 1 | 2 (22.2) | |
| M. hominisa | >12.5 | >12.5 | >12.5 | 50d | >12.5 | >12.5 | >12.5 | >12.5 | >12.5 | >12.5 | >120 | 1 | (0) | |
| No. (%) of AMCs with MICs of ≤12.5 µM | 0 (0) | 3 (75) | 0 (0) | 3 (75) | 1 (25) | 2 (50) | 2 (50) | 1 (25) | 2 (50) | 1 (50) | ||||
a
Tested compounds against this organism in doubling dilutions ranging from 12.5 µM to 1.56 µM.
b
Tested compounds against this organism in doubling dilutions ranging from 25 µM to 3.13 µM, except for compounds 4 and 11, which were tested in doubling dilutions from 12.5 µM to 1.56 µM.
c
Midpoint value of the MIC range from two independent tests.
d
Tested in doubling dilutions ranging from 50 µM to 6.25 µM.
e
NA, not applicable (not tested); QC, quality control; AMC, antimicrobial compounds.