TABLE 3.
MBC results for compounds efficacious against a subset of Ureaplasma species clinical isolates and representative type strains
| Compound, organism | No. of isolates for which MBC was: |
No. (%) of isolates for which treatment was: |
Range or avg (range) MBC (µM) | ||||
|---|---|---|---|---|---|---|---|
| 2× MIC | 4× MIC | >4× MIC | Bactericidal | Bacteriostatic | P value | ||
| Compound 12 | |||||||
| U. urealyticum (n = 5) | 1 | 0 | 4 | 1 (20) | 4 (80) | 0.004 | 6.25 to >12.5 |
| U. parvum (n = 10) | 7 | 3 | 10 (100) | 0 (0) | 12.5 (6.25 to 25) | ||
| Compound 21, Ureaplasma spp. (n = 9) | 1 | 0 | 8 | 1 (11.1) | 8 (88.9) | 12.5 to >12.5 | |