FIG 3.

Osteoarticular tissue- and fluid-to-plasma concentration ratios obtained for vancomycin, linezolid, ertapenem, daptomycin, dalbavancin, and afabicin. Mean ratios (median ratios for ertapenem) were obtained from published data from studies with designs similar to that of this study, i.e., dosing in patients undergoing elective replacement surgery and analysis of the total concentration of the drugs in homogenized bone tissues or synovial fluid collected during surgery (20–25) at steady state for linezolid and afabicin and after a single dose for the other antibiotics. Vancomycin, linezolid, and ertapenem were quantified in serum, whereas daptomycin, dalbavancin, and afabicin desphosphono were quantified in plasma.