FIG 2.

Potential time benefit for effective or definitive therapy. (Top) In scenarios where therapy modifications occurred after traditional AST, returned potential decreases in TTET and TTDT were calculated as the differences in times when traditional final AST results became available and when the ACC results would have been made available. (Bottom) In scenarios where therapy modifications occurred and patients were transitioned to effective or definitive therapy prior to final AST results becoming available, but after the results of ACC would hypothetically have been available, the potential decreases in TTET or TTDT were calculated as the difference between the time of the actual intervention and the time ACC results would have been available. In addition, 2 h was added to the time of ACC results to reflect the time required to address and intervene on ACC results.