TABLE 1.
In vitro interactions by Bliss independence analysis of colistin in combination with rifampin, meropenem, tigecycline, and gentamicin against biofilms of carbapenem-resistant K. pneumoniae isolatesa
| Antibacterial drug combination | Type of interaction | Concn (mg/liter) | Mean % ΔE value (range) | Mean % SE (range) |
|---|---|---|---|---|
| CST + RIF | Synergistic | COL, 32–64; RIF, 0.25–4 | 49.87 (31.63–71.13) | 9.22 (5.83–12.30) |
| CST + MEM | Synergistic | COL, 32; MEM, 0.007–0.25 | 29.52 (23.95–37.26) | 4.97 (4.04–5.54) |
| CST + TGC | Synergistic | COL, 16–32; TGC, 16–64 | 32.44 (28.80–34.56) | 6.49 (6.08–7.64) |
| CST + GEN | Indifferent | ND | ND | ND |
a
ND, not determined.