TABLE 2.

Biological activity of the compounds screened on adult worms^a

Compound plate codeb	MMV identifierc	Mean % mortality for adultsd	SD for % mortality for adultsd
TCBZ	NA	100e	0
PAG6	MMV063404	67	33.3
PBF4	MMV003270	67	0
PBF11	MMV085210	0	0
PBH10	MMV676380	78	19.2
PCC5	MMV687730	11	19.2
PCC6	MMV687251	33	33.3
PCD11	MMV1030799	67	33.3
PCE8	MMV690102	56	19.2
PCE11	MMV1029203	78	19.2
PCF2	MMV676053	0	0
PCF3	MMV688179	22	19.2
PCF4	MMV023969	33	33.3
PCF11	MMV688921	67	33.3

^aCompounds in italics were selected for evaluation of the IC₅₀ for adult worms and for use in the cytotoxicity assay with cell lines. NA, not applicable.

^bCoordinates used to identify the compounds in each plate. TCBZ, triclabendazole.

^cIdentification codes assigned by the Medicines for Malaria Venture (MMV).

^dMeasured at 48 h after drug exposure for adult worms. Results are means and standard deviations from triplicate experiments at a concentration of 33 μM.

^eMean and standard deviation from 6 individual experiments performed in 3 plates.